Klein Independent School District began its drug prevention program during the 1971-1972 school year. Effective with the 1980-1981 school year, Klein enlarged its drug education program to include expanded counseling referral services, increased detection efforts and additional community awareness programs. Since 1981, drug prevention has been included in the curriculum reflecting state mandates that drug prevention be taught to all students. In addition to teaching drug prevention as required by the Texas Essential Knowledge and Skills (TEKS), supplemental instructional materials and co-curricular activities are a part of the drug and violence prevention program of Klein ISD.

Elementary campuses supplement their prevention efforts through the use of Second Step, D.A.R.E., and campus based activities and lessons from sources such as the Texas Drug and Violence Education (D.A.V.E.) Curriculum created under the auspices of the Texas Education Agency. Secondary campuses supplement drug and violence prevention as found in the TEKS with a peer pressure unit for 6th grade students based on the curriculum Here's Looking at You 2000. Follow-up activities in grades 7-8 are based on this curriculum as well as Get Real About Violence. Drug and violence prevention clubs, D.A.V.E., the Skills for Adolescence course, and campus based activities and lessons support prevention at the secondary level.

Help is offered to students by the school nurses, Community Youth Specialists, guidance counselors, and school psychologists and associate psychologists. These persons can direct students and families to agencies in the community which address alcohol and other drug problems. Campus safety is supported by the Klein Police Department and the Human-Canine Drug Surveillance Program